Resumen de Architecture of the RNA polymerase–Spt4/5 complex and basis of universal transcription processivity

Fuensanta W. Martinez Rucobo, Sarah Sainsbury, Alan C.M. Cheung, Patrick Cramer

• Spt5 and NusG play a conserved role in stimulating RNA polymerase II transcription elongation and processivity. Here, the crystal structure of Spt4/5 bound to the RNA polymerase clamp domain reveals that the factor binds above DNA and RNA in the active centre cleft preventing premature dissociation of the polymerase.