Resumen de Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing
Robert Willem van Nues, Sander Granneman, Grzegorz Kudla, Katherine Elizabeth Sloan, Matthew Chicken, David Tollervey, Nicholas J. Watkins
Box C/D small nucleolar RNPs catalyse 2′-O-methylation of eukaryotic ribosomal RNA. A large-scale analysis of yeast box C/D snoRNAs reveals conserved ‘extra base-pairing' between snoRNAs and regions adjacent to their rRNA methylation site and points to a role for the non-catalytic protein subunits Nop56 and Nop58 in rRNA binding.
