Resumen de Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

Ewan Smith, Nadia Hégarat, Clare Vesely, Isaac Roseboom, Chris Larch, Hansjörg Streicher, Kornelis Straatman, Helen Flynn, Mark Skehel, Toru Hirota, Ryoko Kuriyama, Helfrid Hochegger

• Mammalian centrosomes separate prior to mitosis in a process involving Cdk1 and the kinesin Eg5. Dissection by chemical genetics reveals a Cdk1-independent alternative mechanism, in which Plk1 counteracts both centrosomal cohesion factors and Eg5-opposing cytoskeletal forces.