Resumen de Insights into Chi recognition from the structure of an AddAB-type helicase–nuclease complex

Kayarat Saikrishnan, Joseph T Yeeles, Neville S. Gilhooly, Wojciech Krajewski, Mark S. Dillingham, D. B. Wigley

• Homologous recombination DNA repair requires double-strand break resection by helicase–nuclease enzymes. The crystal structure of bacterial AddAB in complex with DNA substrates shows that it employs an inactive helicase site to recognize ‘Chi' recombination hotspot sequences that regulate resection.