Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly

• Jun-ichirou Ohzeki ^[5] ; Jan H Bergmann ^[1] ; Natalay Kouprina ^[2] ; Vladimir N Noskov ^[2] ; Megumi Nakano ^[3] ; Hiroshi Kimura ^[4] ; William C Earnshaw ^[1] ; Vladimir Larionov ^[2] ; Hiroshi Masumoto ^[3]
  1. [1] Wellcome Trust Centre for Cell Biology

     Wellcome Trust Centre for Cell Biology

     Reino Unido

     
  2. [2] National Institutes of Health

     National Institutes of Health

     Estados Unidos

     
  3. [3] Kazusa DNA Research Institute

     Kazusa DNA Research Institute

     Japón

     
  4. [4] Osaka University

     Osaka University

     Kita Ku, Japón

     
  5. [5] Department of Human Genome Research, Laboratory of Cell Engineering, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan; Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 10, 2012, págs. 2391-2402
• Idioma: inglés
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• Resumen

  • Establishment of Human Artificial Chromosomes (HACs) depends on an interplay of H3 lysine 9 modifications at centromeres, providing insights into the pathways that control incorporation of the kinetochore-specificing histone H3 variant CENP-A.