Drug Synthesis and Analysis on a Dime: A Capstone Medicinal Chemistry Experience for the Undergraduate Biochemistry Laboratory

• Craig N. Streu ^[1] ; Randall D. Reif ^[2] ; Kelly Y. Neiles ^[3] ; Amanda J. Schech ^[3] ; Pamela S. Mertz ^[3]
  1. [1] Albion College

     Albion College

     City of Albion, Estados Unidos

     
  2. [2] University of Mary Washington

     University of Mary Washington

     Estados Unidos

     
  3. [3] St. Mary's College of Maryland

     St. Mary's College of Maryland

     Estados Unidos

     

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• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 93, Nº 12, 2016, págs. 2084-2088
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Integrative, research-based experiences have shown tremendous potential as effective pedagogical approaches. Pharmaceutical development is an exciting field that draws heavily on organic chemistry and biochemistry techniques. A capstone drug synthesis/analysis laboratory is described where biochemistry students synthesize azo-stilbenoid compounds and test the biological activity of those compounds as well as a known inhibitor on mushroom tyrosinase using UV/vis-based kinetic assays. In this paper, three such successful azo-stilbenoid inhibitors of tyrosinase, representative student generated data, technical aspects of the experiments, and an interpretation of student feedback on the project as a whole are presented.