Breast-Feeding Modulates the Influence of the Peroxisome Proliferator-Activated Receptor-[gamma] (PPARC2) Pro12Ala Polymorphism on Adiposity in Adolescents

• Autores: Caroline Verier, Aline Meirhaeghe, Szilvia Bokor, C. Breidenassel, Yannis Manios, Denes Molnar, Enrique G. Artero, Esther Nova Rebato, Stefaan de Henauw, Luis A. Moreno Aznar, Philippe Amouyei, Idoia Labayen Goñi
• Localización: Diabetes care, ISSN-e 0149-5992, Vol. 33, Nº. 1 (ENE), 2010, págs. 190-196
• Idioma: inglés
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• Resumen

  • The peroxisome proliferator-activated receptor-ã2 (PPARG2) Pro12Ala polymorphism has been associated with a higher BMI and a lower risk of type 2 diabetes in adulthood. The association between adiposity and PPARG variants can be influenced by environmental factors such as early growth, dietary fat, and (as recently shown) breast-feeding. The objectives of this study were to assess 1) the influence of the PPARG2 Pro12Ala polymorphism on adiposity markers in adolescents and 2) a possible modulating effect of breast-feeding on these associations. Data on breast-feeding duration, BMI, and genotypes for the Prol2Ala polymorphism were available for 945 adolescents (mean age 14.7 years). The breast-feeding duration was obtained from parental records. We measured weight, height, waist circumference, and six skinfold thicknesses. No significant associations between the Pro12Ala polymorphism and any of the above-mentioned anthropometric parameters were found. There were significant interactions between the PPARG2 Pro12Ala polymorphism and breast-feeding with regard to adiposity measurements (all adjusted P < 0.05). Indeed, in children who had not been breast-fed, Ala12 allele carriers had higher adiposity parameters (e. G., Ä BMI +1.88 kg/m^sup 2^, adjusted for age, sex, and center, P = 0.007) than Prol2Pro adolescents. In contrast, in breast-fed subjects, there was no significant difference between Alal2 allele carriers and Prol2Pro children in terms of adiposity measurements, whatever the duration of breast-feeding. Breast-feeding appears to counter the deleterious effect of the PPARG2 Pro12Ala polymorphism on anthropometric parameters in adolescents.