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Resumen de Diagnosis of Bacterial Infection Using a 2-Transcript Host RNA Signature in Febrile Infants 60 Days or Younger

Myrsini Kaforou, Jethro A. Herberg, Victoria J. Wright

  • Distinguishing children with potentially life-threatening bacterial infections from febrile children with viral infections remains a major challenge. Herberg and colleagues,1 in a preliminary, cross-sectional study of 370 febrile children (aged <17 years) in Europe and the United States, reported that children with bacterial infection may be characterized by the difference in blood RNA expression values of 2 genes. In a recent study, Mahajan and colleagues2 reported a 66-transcript blood RNA signature that distinguished bacterial from viral infection in 279 febrile infants younger than 60 days. Young infants are at high risk of bacterial infection; diagnosis is difficult and prompt treatment important. To provide further validation of the 2-gene signature and to evaluate its performance in the infant population, we applied the signature to the RNA expression data of Mahajan et al.


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