Teaching Analytical Method Transfer through Developing and Validating Then Transferring Dissolution Testing Methods for Pharmaceuticals

• Irene Kimaru ^[1] ; Marina Koether ^[2] ; Kimberly Chichester ^[1] ; Lafayette Eaton ^[1]
  1. [1] St. John Fisher College

     St. John Fisher College

     City of Rochester, Estados Unidos

     
  2. [2] Kennesaw State University

     Kennesaw State University

     Estados Unidos

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 94, Nº 8, 2017, págs. 1066-1073
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Analytical method transfer (AMT) and dissolution testing are important topics required in industry that should be taught in analytical chemistry courses. Undergraduate students in senior level analytical chemistry laboratory courses at Kennesaw State University (KSU) and St. John Fisher College (SJFC) participated in development, validation, and transfer of two dissolution testing methods for pharmaceuticals. These experiments were transferred between the two schools and underwent method equivalency testing by a different set of undergraduate students to validate the AMT. Student learning outcomes addressed at both SJFC and KSU include (1) significant learning gains across all 3 years of the study; (2) confidence in method development, writing standard operating procedures, and laboratory transfer of validated methods; (3) increased understanding of AMT and dissolution testing; (4) ability to operate dissolution testers, UV–vis, and flame atomic absorption spectrophotometers; and (5) improved knowledge and understanding of figures of merit and statistical analysis.