Effects of Polysaccharides in Lycium BarbarumBerries from Different Regions of China on Macrophages Function and their Correlation to the Glycosidic Linkages

• Autores: Jing Xie, Ding‐Tao Wu, Wen‐Zhi Li, Chu‐Guang Ning, Yu‐Ping Tang, Jing Zhao, Shao‐Ping Li
• Localización: Journal of food science, ISSN 0022-1147, Vol. 82, Nº 10, 2017, págs. 2411-2420
• Idioma: inglés
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• Resumen

  • Berries of Lycium barbarumL. are not only used for traditional Chinese medicine, but also for raw materials in many health foods. Polysaccharides are major components of L. barbarumberries, which possess a variety of biological activities. In this study, effects of water‐soluble polysaccharides, in 8 typical batches of L. barbarumberries collected from different producing areas of China, on macrophage function were evaluated in vitro. Furthermore, to better understand the structure–activity relationship of the polysaccharides in L. barbarumberries, the activity of typical polysaccharides and their partial acid and enzymatic hydrolysates were also investigated and compared. The results showed that the effects of polysaccharides of different regions are similar, which should be correlated to their similar chemical properties. However, their promotion effects on macrophage function are different in degree, this might be caused by their different content of active polysaccharides. Moreover, the α‐1,4‐d‐galactosiduronic and α‐1,5‐arabinosidic linkages, especially the former one was discovered to significantly affect the promotion effect on macrophage function induced by the polysaccharides in L. barbarumberries. These results were beneficial to improve the pharmacological activity‐based quality control of polysaccharides in L. barbarumberries and their products. The results showed that immunomodulation effects of polysaccharides in L. barbarumberries (LBPs) from different regions are similar, but different in degree, this might be caused by their different content of bioactive polysaccharides. Moreover, an enzymatic digestion method was used to investigate the structure–bioactivity relationship of polysaccharides from LBPs. The result indicated that α‐1,4‐d‐galactosiduronic and α‐1,5‐arabinosidic linkages, especially the former one was significantly affect the immunomodulation effects of LBPs. The results were beneficial to the improvement of pharmacological activity‐based quality control of LBPs and future development of related unique functional and health products.