Arabinoxylan activates lipid catabolism and alleviates liver damage in rats induced by high-fat diet.

• Autores: Hong Chen, Yuanfang Fu, Xiujuan Jiang, Dongmei Li, Wen Qin, Qing Zhang, Derong Lin, Yaowen Liu, Cui Tan, Zhiqing Huang, Yuntao Liu, Daiwen Chen
• Localización: Journal of the science of food and agriculture, ISSN 0022-5142, Vol. 98, Nº 1, 2018, págs. 253-260
• Idioma: inglés
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• Resumen

  • Background: Arabinoxylan was thought to have the potential to change lipid metabolism and redox homeostasis in human and animal. However, the effect of arabinoxylan on the liver damage induced by high-fat diet needs further exploiting.; Results: Six-weeks-old 30 male Sprague-Dawley Rats were assigned randomly to three groups (n = 10 per group), i.e. a control diet (CON) group, a high-fat diet (HF) group and a high-fat diet supplemented with arabinoxylan (6% AX, HF-AX) group. Results showed that final body weight and liver weight were similar in CON group and HF-AX group, but higher in the HF group. In serum, the HF-AX group showed lower triglyceride concentrations than did the HF group. In liver, higher lipoprotein lipase, hepatic lipase, total lipase, and acyl-CoA oxidase activities and lower triglyceride and cholesterol level were observed in the HF-AX group than in the HF group. For the redox homeostasis, arabinoxylan supplemented in HF increased T-SOD activity and GSH-PX activity and reduced MDA + 4-HNE level in liver and/or compared with those in the HF group. Lipid droplets and liver cell damage were observed in the HF group compared with the CON and HF-AX groups.; Conclusion: Arabinoxylan could improve lipid metabolic disorder and alleviate liver damage in rats induced by high-fat diet via activating lipid catabolism and suppressing lipid peroxidation. © 2017 Society of Chemical Industry.; © 2017 Society of Chemical Industry.