Resumen de Multi-regional sequencing elucidates the evolution of clear cell renal cell carcinoma
Christopher J. Ricketts, W. M. Linehan
Extensive multi-regional whole-genome and -exome sequencing performed in tumors from patients with localized, as well as metastatic, clear cell renal cell carcinoma provides a comprehensive description of the tumor origin, intratumoral heterogeneity, evolution, and route to metastasis, laying the foundation for the development of precision clinical management.
