Capstone Laboratory Experiment Investigating Key Features of Palladium-Catalyzed Suzuki–Miyaura Cross-Coupling Reactions

• Reyne Pullen ^[1] ; Angus Olding ^[1] ; Jason A. Smith ^[1] ; Alex C. Bissember ^[1]
  1. [1] University of Tasmania

     University of Tasmania

     Australia

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 95, Nº 11, 2018, págs. 2081-2085
• Idioma: inglés
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• Resumen

  • This two-part laboratory experiment is concerned with investigating key aspects of the Suzuki–Miyaura cross-coupling reaction. The first part of this experiment utilizes high-throughput experimentation techniques to reinforce, explore, and extend fundamental concepts that are presented in the classroom. In contrast, the second part employs guided-inquiry learning strategies to challenge students to design, set up, and perform a preparative-scale Suzuki–Miyaura reaction and suggest workup and isolation protocols. By design, this experiment, which represents one of the final experiments performed in the third-year undergraduate chemistry laboratory program, serves as a capstone learning experience for students.