Solanum muricatum Ameliorates the Symptoms of Osteogenesis Imperfecta In Vivo.

• Wang, Nan ^[1] ; Wang, Luyao ^[2] ; Wang, Zhihong ^[3] ; Cheng, Liangxing ^[4] ; Wang, Jiaxiang ^[5]
  1. [1] Dept. of Emergency Surgery, the First Affiliated Hospital of Zhengzhou Univ., No. 1 Jianshe Rd., Zhengzhou, 450052, Henan, China.
  2. [2] The Center of Stomatology, the First Affiliated Hospital of Zhengzhou Univ., No. 1 Jianshe Rd., Zhengzhou, 450052, Henan, China.
  3. [3] Dept. of Obstetrics and Gynecology, the Second Affiliated Hospital of Zhengzhou Univ., No. 2 Jingba Rd., Zhengzhou, 450014, Henan, China.
  4. [4] Editorial Dept. of Journal of Basic and Clinical Oncology, the First Affiliated Hospital of Zhengzhou Univ., No. 40 Daxue Rd., Zhengzhou, 450052, Henan, China.
  5. [5] Dept. of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou Univ., No. 1 Jianshe Rd., Zhengzhou, 450052, Henan, China.

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• Localización: Journal of food science, ISSN 0022-1147, Vol. 84, Nº 6, 2019, págs. 1646-1650
• Idioma: inglés
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• Resumen

  • Pepino (Solanum muricatum), which is an evergreen plant native to South America, is well-known for its effects in antioxidation, antidiabetic activity, anti-inflammation, and antitumor activity. A previous study in our lab indicated that Solanum muricatum (SM) extract promoted osteogenic differentiation by upregulating Wnt and BMP signaling pathway in rat bone marrow stromal cells. The osteogenesis imperfecta (OI) mouse model was used in order to further discover the osteogenic properties of SM extract in the present research. We utilized microCT analysis to collect bone mass and microarchitectural parameters at vertebrae and at femur metaphysis in OI mice. Raman spectrometry was applied to identify change of bone mineral and matrix composition during SM treatment. Finally, collagen synthesis marker PINP and collagen degradation marker CTX were detected using enzyme immunoassay. SM extract could improve the bone mass and microarchitectural parameters both at vertebrae and at femur metaphysis. It also significantly increased the collagen content by promoting its biosynthesis and inhibiting its degradation. By using heterozygous Col1a1Jrt /+ mice as a model of OI, 6 weeks treatment of SM extract could significantly ameliorate the symptoms in OI mice. Thus, SM holds potential for developing new drugs of bone formation and bone remodeling.; © 2019 Institute of Food Technologists®.