Globally Distributed Drug Discovery of New Antibiotics: Design and Combinatorial Synthesis of Amino Acid Derivatives in the Organic Chemistry Laboratory

• Amy B. Dounay ^[1] ; Martin J. O'Donnell ^[6] ; J. Geno Samaritoni ^[6] ; Lukasz Popiolek ^[2] ; Douglas Schirch ^[3] ; Anna Biernasiuk ^[2] ; Anna Malm ^[2] ; Isaac W. Lamb ^[6] ; Kristen Mudrack ^[4] ; Daniel G. Rivera ^[5] ; Gerardo M. Ojeda ^[5] ; William L. Scott ^[6]
  1. [1] Colorado College

     Colorado College

     Estados Unidos

     
  2. [2] Medical University of Lublin

     Medical University of Lublin

     Lublin, Polonia

     
  3. [3] Goshen College

     Goshen College

     Township of Elkhart, Estados Unidos

     
  4. [4] Milligan College

     Milligan College

     Estados Unidos

     
  5. [5] Universidad de La Habana

     Universidad de La Habana

     Cuba

     
  6. [6] Indiana University−Purdue University Indianapolis, United States

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• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 96, Nº 8, 2019, págs. 1731-1737
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as part of the Distributed Drug Discovery (D3) program. Students use solid-phase synthesis techniques to complete a three-step, combinatorial synthesis of six products, which are analyzed using LC–MS and NMR spectroscopy. This protocol is suitable for introductory organic laboratory students and has been successfully implemented at multiple academic sites internationally. Accompanying prelab activities introduce students to SciFinder and to medicinal chemistry design principles. Pairing of these activities with the laboratory work provides students an authentic and cohesive research project experience.