Resumen de Transcriptional regulation of the bcl-x gene encoding the anti-apoptotic Bcl-xL protein by Ets, Rel/NFkB, STAT and AP1 transcription factor families
L. Sevilla, A. Zaldumbide, P. Pognonec, K. E. Boulukos
Transcription factors play an essential role in determining the fate of a cell by affecting the expression of target genes involved in proliferation , in differentiation and in programmed cell death. Under certain conditions, some of these factors are capable of deregulating expression of genes involved in the cell cycle and/or in programmed cell death resulting in uncontrolled proliferation of the cell. The focus of this review is on the transcriptional regulation of the bel-x gene encoding the anti-apoptotic BcI-xL protein. Since 1999, everal papers have implicated members of the Ets, Rel/NFKB, STAT and AP-l families as transcription factors regulating bel-x expression. A specific emphasis of these different transcription factor families on bel-x regulation in hematopoietic cells is discus ed.
