Resumen de Olanzapina y consumo de cocaína en programa de mantenimiento con metadona
Miguel Angel Landabaso Vázquez, Ioseba Iraurgi Castillo, J. M. Jiménez Lerma, J. Sanz, R. Calle, A. Larrazabal, A. Aizpuru, M. Gutiérrez
Aims: Treatment with olanzapine was evaluated in 27 patients with repeated cocaine consumption without psychotic symptomatology on a methadone program. Patients and methods: Patients were selected from those who presented recurrent positive cocaine urine analysis over a 6-month period. Patients who consented to inclusion in the study received olanzapine 10 mg/d of for the following 6 months. Results: A very significant decrease in positive cocaine and heroin urine analysis was observed (cocaine 36.73% versus 2.38%; heroin 16.60% versus 4.35%). Likewise, a decrease was found in the mean dose of methadone between the previous 6 months and the 6 months on olanzapin. Five of the 27 patients withdrew from the study. Discussion: Olanzapine administration may favor compliance with the methadone program allowing a reduction in the daily dose of methadone and an important decrease in the consumption of cocaine and/or heroin.
