A Pedagogical Introduction to Biomarker Detection in Surface-Based Biosensors
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Praneet Prakash [1] ; Manoj Varma [2]
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[1] University of Cambridge
University of Cambridge
Cambridge District, Reino Unido
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[2] Indian Institute of Science, India
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- Localización: Journal of chemical education, ISSN 0021-9584, Vol. 99, Nº 11, 2022, págs. 3694-3701
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
The field of biosensors is a burgeoning area of research and employs a large number of chemistry graduates. The impact of strip tests in detecting coronavirus was palpable during the recent COVID-19 pandemic and will further drive the biosensor industry. Despite their common usage, a coherent introduction to the basics of sensing remains missing from the chemistry curriculum. Through this work, key concepts of transport and noise interference in molecular sensing aimed at upper-level coursework are introduced. Exercises including teamwork activities are proposed for teaching and inquiry-based learning. The presented approach was effective in solidifying the concepts of molecular transport and competing binding kinetics. Furthermore, students are introduced to an online database on biomarkers and open-source binding affinity resources. The material can be seamlessly integrated into the existing coursework by expanding discussions on binding kinetics and equilibrium.
