Growing human organs inside animals

• Autores: Julian Koplin, Neera Bhatia
• Localización: Handbook of bioethical decisions / coord. por Erick Valdés, Juan Alberto Lecaros Urzúa, Vol. 1, 2023 (Handbook of Bioethical Decisions. Volume I. Decisions at the Bench), ISBN 9783031294501, págs. 607-623
• Idioma: inglés
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• Resumen

  • This chapter considers the prospect of generating human organs within chimeric animals comprised of a mix of human and animal cells. Although seemingly farfetched – the term ‘chimera’ even means, in some modern usage, a “mere wild fancy” or “unfounded conception” (Oxford English Dictionary (n.d.) ‘chimera | chimaera, n.’, OED Online. Oxford University Press. Available at: https://www.oed.com/view/Entry/31708) – recent research into interspecies blastocyst complementation is paving the way toward growing human organs inside of human-animal chimeras, potentially within the not-too-distant future Zheng et al. (Development 148(12), 2021). These human-animal chimeras promise important advances within regenerative medicine and medical research. They also raise some profound bioethical issues, which we survey below.