Resumen de Synthesis of 2-aryl-1,3-propanediamines using a one-pot knoevenagel-michael sequence

Patricio Iturriaga-vásquez, Susan Lühr-sierra, Marcos Caroli Rezende, Bruce K Cassels

• A simple synthetic route for the preparation of 2-phenyl-1,3-propanediamines, based on a Knoevenagel-Michael double condensation followed by reduction, was developed using nitromethane as reagent and solvent, and sodium bicarbonate as base in the first step, followed by catalytic hydrogenation over Adams catalyst