Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens: potential for the food and pharmaceutical sectors

• Mohamed Taibi ^[1] ; Amine Elbouzidi ^[1] ; Mounir Haddou ^[1] ; Yousra Belbachir ^[1] ; Abdellah Baraich ^[1] ; Zineb Khalil ^[2] ; Reda Bellaouchi ^[1] ; Abdeslam Asehraou ^[1] ; Mohamed Addi ^[1] ; Ammar AL-Farga ^[3] ; Saleh M. Al-Maaqa ^[4] ; Bouchra El Guerrou ^[1] ; Khalid Chaabane ^[1]
  1. [1] Université Mohammed Premier
  2. [2] Higher Institute of Nursing Professions and Healthcare Techniques, Casablanca
  3. [3] University of Jeddah
  4. [4] Albaydha University

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• Localización: CyTA: Journal of food, ISSN 1947-6337, ISSN-e 1947-6345, Vol. 22, Nº. 1, 2024
• Idioma: inglés
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  • This study delves into the biological characteristics of Clinopodium nepeta subsp. ascendens (CNEO) essential oil, an indigenous subspecies of eastern Morocco. Distinguished by its purple or pale pinkish-white flowers, CNEO was subjected to thorough phytochemical analysis via gas chromatography-mass spectrometry (GC-MS), revealing 21 terpene compounds, notably Dihydrocarvone (22.70%), Neoisomenthol (43.59%), and Pulegone (20.55%). These compounds, recognized for their biological and pharmacological attributes, were further investigated for their potential applications. Notably, CNEO exhibited dose-dependent anti-inflammatory effects by attenuating nitric oxide (NO) and prostaglandin E2 (PGE2) production. Moreover, it demonstrated promising anticancer activity against MDA-MB-468, HepG2, and HCT-15 cancer cell lines, rivaling doxorubicin’s effectiveness. These findings underscore CNEO’s nutraceutical potential, particularly in food science and industry, suggesting its use as a functional food additive with both nutritional and health benefits