Resumen de Cyclobutane-containing peptides and ureas: synthesis, folding, self-assembling and some biological properties
Peptides and relative compounds, have been widely used and studied during the past decades. In the present thesis, an enantioselective synthesis and structural study of a variety of cyclobutane-containing beta-peptides and ureas is exposed. By means of experimental and theoretical techniques, their adoption of different folding structures due to the presence of self-assembling properties is described. These properties, in some cases, allowed the preparation of stable gels in organic solvents, which obtaintion was fully studied.
In addition, the use of solid-phase peptide synthesis strategy was assaied in order to prepare hybrid cyclobutane-proline hexapeptides. Those, were studied as possible cell-penetrating agents.
