25-Hydroxyvitamin D levels of children are inversely related to adiposity assessed by body mass index

Silvia Barja Fernández; María Rosaura Leis Trabazo; Concepción M. Aguilera; Isabel Martínez Silva; Rocío Vázquez Vigo; Mercedes Gil Campos; Josune Olza; Juan E. Bedoya Arias; Carmen María Cadarso Suárez; Ángel Gil Hernández; Luisa M. Seoane

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25-Hydroxyvitamin D levels of children are inversely related to adiposity assessed by body mass index

Silvia Barja-Fernández ^[1] ; Rosaura Leis ^[1] ; Concepción M. Aguilera ^[2] ; Isabel Martínez-Silva ^[3] ; Rocío Vazquez ^[1] ; Mercedes Gil-Campos ^[4] ; Josune Olza ^[2] ; Juan Bedoya ^[1] ; Carmen Cadarso-Suárez ^[5] ; Ángel Gil ^[2] ; Luisa M. Seoane ^[1]
1. [1] Complexo Hospitalario Universitario de Santiago
  
  Complexo Hospitalario Universitario de Santiago
  
  Santiago de Compostela, España
2. [2] Center for Biomedical Research (UGR)GranadaSpain
3. [3] University of VigoVigoSpain
4. [4] Reina Sofia University Hospital (IMIBIC)CórdobaSpain
5. [5] University of Santiago de CompostelaSantiago de CompostelaSpain
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Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 74, Nº. 1, 2018, págs. 111-118
Idioma: inglés
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Resumen
- Vitamin D deficiency is associated with wide range of pathologies. Some evidences have shown that low vitamin D circulating levels in children and adolescent are related to fat mass and obesity. The objectives of the present study were to characterize vitamin D status in children and adolescents and to determine if serum 25-hydroxyvitamin D (25(OH)D) concentration is related to adiposity assessed by body mass index (BMI). Serum 25(OH)D levels were measured by LIAISON method in 471 children and adolescents (2 to 18 years age) and analyzed according to gender, pubertal period, age, and BMI. An overall prevalence of 25(OH)D insufficiency and deficiency was present in the 67.1%. Lower 25(OH)D levels were found in females (25.56 ± 14.03 vs 29.71 ± 17.10 ng ml−1; P = 0.004) and pubertal children (25.52 ± 13.97 vs 29.21 ± 16.83 ng ml−1; P = 0.011). In addition, an inverse relation of BMI and age on 25(OH)D concentrations was observed in children. In conclusion, low vitamin D status was highly prevalent among children and adolescents. Of note, a non-lineal regression model showed that 39.6% of vitamin D levels variability was explained by BMI. These results indicate that adiposity assessed by BMI impacts vitamin D status.