Curcumin: recent updates on gastrointestinal cancers

• Muhammad Imran ^[8] ; Farhan Saeed ^[9] ; Suliman A. Alsagaby ^[1] ; Ali Imran ^[9] ; Ishtiaque Ahmad ^[10] ; Ahmad H. El Ghorab ^[2] ; Mohamed A. Abdelgawad ^[2] ; Tahira Batool Qaisrani ^[3] ; Tahir Mehmood ^[4] ; Maryam Umar ^[9] ; Muhammad Arslan Mumtaz ^[5] ; Arfaa Sajid ^[6] ; Qaisar Manzoor ^[6] ; Muzzamal Hussain ^[9] ; Waleed Al Abdulmonem ^[7] ; Entessar Al Jbawi ^[11]
  1. [1] Majmaah University

     Majmaah University

     Arabia Saudí

     
  2. [2] Al Jouf University

     Al Jouf University

     Arabia Saudí

     
  3. [3] Ghazi University

     Ghazi University

     Pakistán

     
  4. [4] Islamia University of Bahawalpur

     Islamia University of Bahawalpur

     Pakistán

     
  5. [5] Mayo Hospital

     Mayo Hospital

     Pakistán

     
  6. [6] University of Lahore

     University of Lahore

     Pakistán

     
  7. [7] Qassim University

     Qassim University

     Arabia Saudí

     
  8. [8] University of Narowal
  9. [9] Government College University, Faisalabad
  10. [10] University of Veterinary & Animal Sciences (UVAS)
  11. [11] Agricultural Extension Directorate, MAAR

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• Localización: CyTA: Journal of food, ISSN 1947-6337, ISSN-e 1947-6345, Vol. 21, Nº. 1, 2023, págs. 502-513
• Idioma: inglés
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• Resumen

  • Curcumin is a phenolic pigment, naturally present in Curcuma longa species. It is a yellow active ingredient and shows a pivotal role in the modulation of biological processes resulting in the prevention of cancer particularly due to its radical scavenging activities. In gastrointestinal cancer cells, curcumin has been shown to induce cell death through apoptosis and to cause cell cycle arrest, down-regulating glycolytic enzyme expressions alongside inhibition of the matrix metalloproteinase-2 (MMP-2) promoter activity and SDF-1α-induced cell invasion. It also activates the expression of cleaved caspase-3, reduces cell viability, regulates the ratio of Bcl-2/Bax, decreases the number of cells in the proliferative G0/G1 phase and increases the number of cells in the S phase. Additionally, curcumin prevents DNA from replication during the S phase. This review discusses the chemo-preventive role of curcumin and its mechanisms against human gastrointestinal cancers to understand its activity and potential utilization as a therapeutic moiety.